Prof. Stefano Marini
Contact details
Professor in Chemistry and Biochemistry,
Faculty of Medicine, University of Rome Tor Vergata, Rome, Italy.
Via Montpellier 1, 00133 Rome
Office: Department of Experimental Medicine and Biochemical Sciences
Tel: +39 06 72596354
Research Activity
1) Laboratory development and managing.
2) Molecular biology techniques
3) Microbiology techniques.
4) Immunobiosensors for analisys of enviromental pollution and food contaminants.
5) Cellular immunology
6) Immunochemistry
7) Cell culture and monoclonal antibody production
8) Drug design and HTS
9) Activity evaluation of new drugs against parasites.
Recent Publications
[1]. Ciaccio C, Coletta A, De Sanctis G, Marini S., Coletta M. (2008) Cooperativity and allostery in haemoglobin function. IUBMB Life. Feb;60(2):112-23
[2]. Gemma S, Campiani G, Butini S, Kukreja G, Coccone SS, Joshi BP, Persico M, Nacci V, Fiorini I, Novellino E, Fattorusso E, Taglialatela-Scafati O, Savini L, Taramelli D, Basilico N, Parapini S, Morace G, Yardley V, Croft S, Coletta M, Marini S, Fattorusso C. (2008) Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies. J Med Chem. 2008 Mar 13;51(5):1278-94. Epub 2008 Feb 16.
[3]. Monaco S, Gioia M, Rodriguez J, Fasciglione GF, Di Pierro D, Lupidi G, Krippahl L, Marini S, Coletta M. (2007) Modulation of the proteolytic activity of matrix metalloproteinase-2 (gelatinase A) on fibrinogen. Biochem J. Mar 15;402(3):503-13.
[4]. Saladino R, Fiani C, Crestini C, Argyropoulos DS, Marini S, Coletta M. (2007) An efficient and stereoselective dearylation of asarinin and sesamin tetrahydrofurofuran lignans to acuminatolide by methyltrioxorhenium/H(2)O(2) and UHP systems. J Nat Prod. Jan;70(1):39-42.
[5]. Gioia M, Monaco S, Fasciglione GF, Coletti A, Modesti A, Marini S, Coletta M. (2007) Characterization of the Mechanisms by which Gelatinase A, Neutrophil Collagenase, and Membrane-Type Metalloproteinase MMP-14 Recognize Collagen I and Enzymatically Process the Two alpha-Chains. J Mol Biol. May 11;368(4):1101-1113. Epub 2007 Mar 2.
Prof. Mauro Maccarrone
Contact details
Full Professor in Biochemistry at the School of Veterinary Medicine,
University of Teramo, Italy.
Visiting Professor at the School of Medicine,
University of Rome “Tor Vergata”, Italy.
Tel.: 0861266875
Tel.: 0672596388
Research Activity
Published 207 full papers including 32 review articles (total I.F. ≈ 800), and 43 invited papers in international refereed journals, besides 41 mini-papers and 128 Congress communications on the following main topics:
1. Structure and function of enzymes; 2. Membranes and lipid messengers in programmed cell death (apoptosis) and in neurodegenerative processes; 3. Endocannabinoids; 4. Ultraweak luminescence in biomedicine; 5. Gravitational effects on enzyme reactions.
Recent Publications
[1] Dainese E, Oddi S, Maccarrone M.
Lipid-mediated dimerization of beta(2)-adrenergic receptor reveals important clues for cannabinoid receptors.
Cell Mol Life Sci. 2008 May 26.
[2] Battista N, Pasquariello N, Di Tommaso M, Maccarrone M.
Interplay between endocannabinoids, steroids and cytokines in the control of human reproduction.
J Neuroendocrinol. 2008 May;20 Suppl 1:82-9.
[3] Di Marzo V, Maccarrone M.
FAAH and anandamide: is 2-AG really the odd one out?
Trends Pharmacol Sci. 2008 May;29(5):229-233.
[4] Cupini LM, Costa C, Sarchielli P, Bari M, Battista N, Eusebi P, Calabresi P, Maccarrone M.
Degradation of endocannabinoids in chronic migraine and medication overuse headache.
Neurobiol Dis. 2008 May;30(2):186-9.
[5] Battista N, Rapino C, Di Tommaso M, Bari M, Pasquariello N, Maccarrone M.
Regulation of male fertility by the endocannabinoid system.
Mol Cell Endocrinol. 2008 Apr 16;286(1-2 Suppl 1):S17-23.
[6] Kurtuncu M, Battista N, Uz T, D’Agostino A, Dimitrijevic N, Pasquariello N, Manev R, Maccarrone M, Manev H.
Effects of cocaine in 5-lipoxygenase-deficient mice.
J Neural Transm. 2008;115(3):389-95.
Joint Laboratory Tor Vergata University - NAST Centre- Tokyo University
Prof. Laura Fiorucci
Contact details
Professor of Biochemistry at the Faculty of Medicine
University of Rome Tor Vergata
Via Montpellier 1, 00133 Rome
Office: Department of Experimental Medicine and Biochemical Sciences
Tel: +39 06 72596478
Research Activity
Scientific topics: A. Proteases and inhibitors: mast cell proteases, structural and functional studies, interaction with endogenous inhibitors, search for new inhibitors;. B. Protein folding/unfolding of cytochrome c as probed by limited proteolysis, its interaction with lipids and search for the structural requirements for its pro-apoptotic activity.
Recent Publications
[1] Sinibaldi F, Fiorucci L, Patriarca A, Lauceri R, Ferri T, Coletta M, Santucci R. Insights into Cytochrome c-Cardiolipin Interaction. Role Played by Ionic Strength (2008) Biochemistry. [Epub ahead of print]
[2] Santucci R., Sinibaldi F., Fiorucci L. Protein Folding, Unfolding and Misfolding Role Played by Intermediate States Mini-Reviews in Medicinal Chemistry, 2008, 8, 000-000 1
[3]Agueci F., Polticelli F., Sinibaldi F., Piro M.C., Santucci R., Fiorucci L. (2007) Probing the effect of mutations on cytochrome c stability Protein and Peptide Letters, 14, 335-339 ISSN 0929-8665
[4]Sinibaldi F., Mei G., Ponticelli F., Piro M.C., Howes, B.D., Smulevich G., Santucci R., Ascoli F., Fiorucci L. (2005) ATP specifically driver refolding of non native conformations of cytochrome c Protein Science 14: 1049-1058 ISSN 0961-8368
Open Position 3
NO POSITION AVAILABLE
Title of the Research project